51±ľÉ«

Zusammenstellung von Bildern aus dem Sonderforschungsbereich

CRC related publications

2022

368.
M. Groger, M. Hogg, E. Abdelsalam, S. Kress, A. Hoffmann, B. Stahl, V. Saub, N. Denoix, O. McCook, E. Calzia, E. M. Wolfschmitt, U. Wachter, J. A. Vogt, R. Wang, P. Radermacher, T. Merz and B. L. Nussbaum, "Effects of Sodium Thiosulfate During Resuscitation from Trauma-and-Hemorrhage in Cystathionine gamma-Lyase (CSE) Knockout Mice", Shock, vol. 57, no. 1, pp. 131-139, 2022.
DOI:
File:
367.
M. Groger, M. Hogg, E. Abdelsalam, S. Kress, A. Hoffmann, B. Stahl, E. Calzia, U. Wachter, J. A. Vogt, R. Wang, T. Merz, P. Radermacher and O. McCook, "Effects of Sodium Thiosulfate During Resuscitation From Trauma-and-Hemorrhage in Cystathionine-gamma-Lyase Knockout Mice With Diabetes Type 1", Front Med (Lausanne), vol. 9, pp. 878823, 2022.
DOI:
File:
366.
U. Stifel, E. M. Wolfschmitt, J. Vogt, U. Wachter, S. Vettorazzi, D. Tews, M. Hogg, F. Zink, N. M. Koll, S. Winning, R. Mounier, B. Chazaud, P. Radermacher, P. Fischer-Posovszky, G. Caratti and J. Tuckermann, "Glucocorticoids coordinate macrophage metabolism through the regulation of the tricarboxylic acid cycle", Mol Metab, vol. 57, pp. 101424, 2022.
DOI:
File:
365.
T. Merz, O. McCook, C. Brucker, C. Waller, E. Calzia, P. Radermacher and T. Datzmann, "H(2)S in Critical Illness-A New Horizon for Sodium Thiosulfate?", Biomolecules, vol. 12, no. 4, 2022.
DOI:
File:
364.
J. M. Preuss, U. Burret, M. Groger, S. Kress, A. Scheuerle, P. Möller, J. P. Tuckermann, M. Wepler and S. Vettorazzi, "Impaired Glucocorticoid Receptor Signaling Aggravates Lung Injury after Hemorrhagic Shock", Cells, vol. 11, no. 1, pp. 112, 2022.
DOI:
File:
363.
V. Kirsch, J. M. Ramge, A. Schoppa, A. Ignatius and J. Riegger, "In Vitro Characterization of Doxorubicin-Mediated Stress-Induced Premature Senescence in Human Chondrocytes", Cells, vol. 11, no. 7, pp. 1106, 2022.
DOI:
File:
362.
Y. Lai, G. Fois, J. R. Flores, M. J. Tuvim, Q. Zhou, K. Yang, J. Leitz, J. Peters, Y. Zhang, R. A. Pfuetzner, L. Esquivies, P. Jones, M. Frick, B. F. Dickey and A. T. Brunger, "Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides", Nature, vol. 603, no. 7903, pp. 949-956, 2022.
DOI:
File:
361.
B. T. KrĂĽger, L. Steppe, S. Vettorazzi, M. Haffner-Luntzer, S. Lee, A. K. Dorn, A. Ignatius, J. Tuckermann and M. Ahmad, "Inhibition of Cdk5 Ameliorates Skeletal Bone Loss in Glucocorticoid-Treated Mice", Biomedicines, vol. 10, no. 2, pp. 404, 2022.
DOI:
File:
360.
M. Ahmad, B. T. KrĂĽger, T. Kroll, S. Vettorazzi, A. K. Dorn, F. Mengele, S. Lee, S. Nandi, D. Yilmaz, M. Stolz, N. K. Tangudu, D. C. Vazquez, J. Pachmayr, I. C. Cirstea, M. V. Spasic, A. Ploubidou, A. Ignatius and J. Tuckermann, "Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing", Bone Res, vol. 10, no. 1, pp. 33, 2022.
DOI:
File:
359.
V. Fischer and M. Haffner-Luntzer, "Interaction between bone and immune cells: Implications for postmenopausal osteoporosis", Semin Cell Dev Biol, vol. 123, pp. 14-21, 2022.
DOI:
File:
358.
V. Fischer, D. Ragipoglu, J. Diedrich, L. Steppe, A. Dudeck, K. Schutze, M. Kalbitz, F. Gebhard, M. Haffner-Luntzer and A. Ignatius, "Mast Cells Trigger Disturbed Bone Healing in Osteoporotic Mice", J Bone Miner Res, vol. 37, no. 1, pp. 137-151, 2022.
DOI:
File:
357.
S. Meyer Zu Reckendorf, D. Moser, A. Blechschmidt, V. N. Joga, D. Sinske, J. Hegler, S. Deininger, A. Catanese, S. Vettorazzi, G. Antoniadis, T. Boeckers and B. Knöll, "Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Also Regeneration after Facial Nerve Injury", J Neurosci, vol. 42, no. 12, pp. 2474-2491, 2022.
DOI:
File:
356.
J. Bernhardi and L. Dimou, "Oligodendrogenesis is a key process for cognitive performance improvement induced by voluntary physical activity", Glia, vol. 70, no. 6, pp. 1052-1067, 2022.
DOI:
File:
355.
A. Gihring, F. Gärtner, M. Schirmer, M. Wabitsch and U. Knippschild, "Recent Developments in Mouse Trauma Research Models: A Mini-Review", Front Physiol, vol. 13, pp. 866617, 2022.
DOI:
File:
354.
T. Datzmann, D. A. C. Messerer, F. MĂĽnz, A. Hoffmann, M. Groger, R. Mathieu, S. Mayer, H. Gassler, F. Zink, O. McCook, T. Merz, A. Scheuerle, E. M. Wolfschmitt, T. Thebrath, S. Zuech, E. Calzia, P. Asfar, P. Radermacher and T. Kapapa, "The effect of targeted hyperoxemia in a randomized controlled trial employing a long-term resuscitated, model of combined acute subdural hematoma and hemorrhagic shock in swine with coronary artery disease: An exploratory, hypothesis-generating study", Front Med (Lausanne), vol. 9, pp. 971882, 2022.
DOI:
File:
353.
I. M. Sehring and G. Weidinger, "The fin roundabout: Slit-Robo and S1P signaling coordinate fin morphogenesis", EMBO Rep, vol. 23, no. 8, pp. e55563, 2022.
DOI:
File:
352.
D. A. C. Messerer, H. Gaessler, A. Hoffmann, M. Groger, K. Benz, A. Huhn, F. Hezel, E. Calzia, P. Radermacher and T. Datzmann, "The H(2)S Donor Sodium Thiosulfate (Na(2)S(2)O(3)) Does Not Improve Inflammation and Organ Damage After Hemorrhagic Shock in Cardiovascular Healthy Swine", Front Immunol, vol. 13, pp. 901005, 2022.
DOI:
File:
351.
J. Eisele, S. Schreiner, J. Borho, S. Fischer, S. Heber, S. Endres, M. Fellermann, L. Wohlgemuth, M. Huber-Lang, G. Fois, M. Fauler, M. Frick and H. Barth, "The Pore-Forming Subunit C2IIa of the Binary Clostridium botulinum C2 Toxin Reduces the Chemotactic Translocation of Human Polymorphonuclear Leukocytes", Front Pharmacol, vol. 13, pp. 810611, 2022.
DOI:
File:
350.
A. Kerstan, K. Dieter, E. Niebergall-Roth, S. Klingele, M. Junger, C. Hasslacher, G. Daeschlein, L. Stemler, U. Meyer-Pannwitt, K. Schubert, G. Klausmann, T. Raab, M. Goebeler, K. Kraft, J. Esterlechner, H. M. Schroder, S. Sadeghi, S. Ballikaya, M. Gasser, A. M. Waaga-Gasser, G. F. Murphy, D. P. Orgill, N. Y. Frank, C. Ganss, K. Scharffetter-Kochanek, M. H. Frank and M. A. Kluth, "Translational development of ABCB5(+) dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers", Stem Cell Res Ther, vol. 13, no. 1, pp. 455, 2022.
DOI:
File:
349.
A. Bertozzi, C. C. Wu, S. Hans and G. Weidinger, "Wnt/beta-catenin signaling acts cell-autonomously to promote cardiomyocyte regeneration in the zebrafish heart", Dev Biol, vol. 481, pp. 226-237, 2022.
DOI:
File:
348.
I. Sehring, H. F. Mohammadi, M. Haffner-Luntzer, A. Ignatius, M. Huber-Lang and G. Weidinger, "Zebrafish fin regeneration involves generic and regeneration-specific osteoblast injury responses", Elife, vol. 11, 2022.
DOI:
File:
347.
I. Sehring, M. Haffner-Luntzer, A. Ignatius, M. Huber-Lang and G. Weidinger, "Zebrafish fin regeneration requires generic and regeneration-specific responses of osteoblasts to trauma", bioRxiv, 2022.
DOI:
346.
A. K. Sauer, S. Malijauskaite, P. Meleady, T. M. Boeckers, K. McGourty and A. M. Grabrucker, "Zinc is a key regulator of gastrointestinal development, microbiota composition and inflammation with relevance for autism spectrum disorders", Cellular and Molecular Life Sciences, vol. 79, no. 1, pp. 18, 2022.
DOI:
File:pdf

2021

345.
C. Leinert, S. Brefka, U. Braisch, N. Denninger, M. Mueller, P. Benzinger, J. Bauer, A. Bahrmann, N. Frey, H. A. Katus, T. Geisler, G. Eschweiler, J. Klaus, T. Seufferlein, K. Schuetze, F. Gebhard, J. Dreyhaupt, R. Muche, K. Pahmeier, J. Biermann-Stallwitz, J. Wasem, L. Flagmeier, D. Dallmeier and M. Denkinger, "A complex intervention to promote prevention of delirium in older adults by targeting caregiver's participation during and after hospital discharge - study protocol of the TRAnsport and DElirium in older people (TRADE) project", BMC Geriatr, vol. 21, no. 1, pp. 646, 2021.
DOI:
File:pdf
344.
S. Cursano, C. R. Battaglia, C. Urrutia-Ruiz, S. Grabrucker, M. Schon, J. Bockmann, S. Braumuller, P. Radermacher, F. Roselli, M. Huber-Lang and T. M. Boeckers, "A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome", Mol Psychiatry, vol. 26, no. 8, pp. 3778-3794, 2021.
DOI:
File:pdf
343.
S. Vettorazzi, D. Nalbantoglu, J. C. M. Gebhardt and J. Tuckermann, "A guide to changing paradigms of glucocorticoid receptor function-a model system for genome regulation and physiology", FEBS J, 2021.
DOI:
File:
342.
P. H. Richter, A. Blidon, A. Eickhoff, F. Gebhard and K. Schuetze, "Accuracy of screw stabilization of the dorsal pelvic ring using a hybrid operating room: 5 Year experience in a level 1 trauma center", Injury, vol. 52, no. 10, pp. 2968-2972, 2021.
DOI:
File:
341.
S. Hug, S. Bernhard, A. E. P. Stratmann, M. Erber, L. Wohlgemuth, C. L. Knapp, J. M. Bauer, L. Vidoni, M. Fauler, K. J. Fohr, P. Radermacher, A. Hoffmann, M. Huber-Lang and D. A. C. Messerer, "Activation of Neutrophil Granulocytes by Platelet-Activating Factor Is Impaired During Experimental Sepsis", Front Immunol, vol. 12, pp. 642867, 2021.
DOI:
File:pdf
340.
S. Grabrucker, J. Pagano, J. Schweizer, C. Urrutia-Ruiz, M. Schon, K. Thome, G. Ehret, A. M. Grabrucker, R. Zhang, B. Hengerer, J. Bockmann, C. Verpelli, C. Sala and T. M. Boeckers, "Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism", Embo Journal, vol. 40, no. 5, pp. 19, 2021.
DOI:
File:
339.
R. Rehman, L. Tar, A. J. Olamide, Z. Li, J. Kassubek, T. Böckers, J. Weishaupt, A. Ludolph, D. Wiesner and F. Roselli, "Acute TBK1/IKK-epsilon Inhibition Enhances the Generation of Disease-Associated Microglia-Like Phenotype Upon Cortical Stab-Wound Injury", Front Aging Neurosci, vol. 13, pp. 684171, 2021.
DOI:
File:pdf
338.
M. Barnea-Zohar, S. E. Winograd-Katz, M. Shalev, E. Arman, N. Reuven, L. Roth, O. Golani, M. Stein, F. Thalji, M. Kanaan, J. Tuckermann, B. Geiger and A. Elson, "An SNX10-dependent mechanism downregulates fusion between mature osteoclasts", J Cell Sci, vol. 134, no. 9, pp. jcs254979, 2021.
DOI:
File:
337.
T. Merz, O. McCook, N. Denoix, P. Radermacher, C. Waller and T. Kapapa, "Biological Connection of Psychological Stress and Polytrauma under Intensive Care: The Role of Oxytocin and Hydrogen Sulfide", Int J Mol Sci, vol. 22, no. 17, pp. 9192, 2021.
DOI:
File:pdf
336.
E. Kempter, M. Amoroso, H. L. Duffner, A. M. Werner, D. Langgartner, S. Kupfer and S. O. Reber, "Changes in Functional Glucocorticoid Sensitivity of Isolated Splenocytes Induced by Chronic Psychosocial Stress - A Time Course Study", Front Immunol, vol. 12, pp. 753822, 2021.
DOI:
File:pdf
335.
K. Ernst, M. Landenberger, J. Nieland, K. Norgaard, M. Frick, G. Fois, R. Benz and H. Barth, "Characterization and Pharmacological Inhibition of the Pore-Forming Clostridioides difficile CDTb Toxin", Toxins (Basel), vol. 13, no. 6, pp. 390, 2021.
DOI:
File:pdf
334.
M. Mannes, C. Q. Schmidt, B. Nilsson, K. N. Ekdahl and M. Huber-Lang, "Complement as driver of systemic inflammation and organ failure in trauma, burn, and sepsis", Semin Immunopathol, vol. 43, no. 6, pp. 773-788, 2021.
DOI:
File:pdf
333.
C. Ehrnthaller, S. Braumuller, S. Kellermann, F. Gebhard, M. Perl and M. Huber-Lang, "Complement Factor C5a Inhibits Apoptosis of Neutrophils-A Mechanism in Polytrauma?", J Clin Med, vol. 10, no. 14, pp. 3157, 2021.
DOI:
File:pdf
332.
M. S. Huber-Lang, A. Ignatius, J. Kohl, M. Mannes and C. K. Braun, "Complement in Trauma - Traumatised Complement?", Br J Pharmacol, vol. 178, no. 14, pp. 2863-2879, 2021.
DOI:
File:
331.
M. Mannes, A. Dopler, O. Zolk, S. J. Lang, R. Halbgebauer, B. Hochsmann, A. Skerra, C. K. Braun, M. Huber-Lang, H. Schrezenmeier and C. Q. Schmidt, "Complement inhibition at the level of C3 or C5: mechanistic reasons for ongoing terminal pathway activity", Blood, vol. 137, no. 4, pp. 443-455, 2021.
DOI:
File:
330.
J. Scekic-Zahirovic, I. Sanjuan-Ruiz, V. Kan, S. Megat, P. De Rossi, S. Dieterle, R. Cassel, M. Jamet, P. Kessler, D. Wiesner, L. Tzeplaeff, V. Demais, S. Sahadevan, K. M. Hembach, H. P. Muller, G. Picchiarelli, N. Mishra, S. Antonucci, S. Dirrig-Grosch, J. Kassubek, V. Rasche, A. Ludolph, A. L. Boutillier, F. Roselli, M. Polymenidou, C. Lagier-Tourenne, S. Liebscher and L. Dupuis, "Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects", Nat Commun, vol. 12, no. 1, pp. 3028, 2021.
DOI:
File:pdf
329.
M. Singer, P. J. Young, J. G. Laffey, P. Asfar, F. S. Taccone, M. B. Skrifvars, C. S. Meyhoff and P. Radermacher, "Dangers of hyperoxia", Crit Care, vol. 25, no. 1, pp. 440, 2021.
DOI:
File:
328.
P. Pfänder, A. K. Eiers, U. Burret and S. Vettorazzi, "Deletion of Cdk5 in Macrophages Ameliorates Anti-Inflammatory Response during Endotoxemia through Induction of C-Maf and Il-10", Int J Mol Sci, vol. 22, no. 17, pp. 9648, 2021.
DOI:
File:pdf
327.
B. Trautwein, T. Merz, N. Denoix, C. Szabo, E. Calzia, P. Radermacher and O. McCook, "DeltaMST and the Regulation of Cardiac CSE and OTR Expression in Trauma and Hemorrhage", Antioxidants (Basel), vol. 10, no. 2, pp. 233, 2021.
DOI:
File:pdf
326.
A. Mossa, J. Pagano, L. Ponzoni, A. Tozzi, E. Vezzoli, M. Sciaccaluga, C. Costa, S. Beretta, M. Francolini, M. Sala, P. Calabresi, T. M. Boeckers, C. Sala and C. Verpelli, "Developmental impaired Akt signaling in the Shank1 and Shank3 double knock-out mice", Molecular Psychiatry, vol. 26, pp. 1928–1944, 2021.
DOI:
File:pdf
325.
M. Haffner-Luntzer, V. Fischer and A. Ignatius, "Differences in Fracture Healing Between Female and Male C57BL/6J Mice", Front Physiol, vol. 12, pp. 712494, 2021.
DOI:
File:
324.
Z. Li, J. Zhang, S. Halbgebauer, A. Chandrasekar, R. Rehman, A. Ludolph, T. Boeckers, M. Huber-Lang, M. Otto, F. Roselli and F. O. Heuvel, "Differential effect of ethanol intoxication on peripheral markers of cerebral injury in murine blunt traumatic brain injury", Burns Trauma, vol. 9, pp. tkab027, 2021.
DOI:
File:pdf
323.
D. Bayer, S. Antonucci, H. P. Muller, R. Saad, L. Dupuis, V. Rasche, T. M. Böckers, A. C. Ludolph, J. Kassubek and F. Roselli, "Disruption of orbitofrontal-hypothalamic projections in a murine ALS model and in human patients", Transl Neurodegener, vol. 10, no. 1, pp. 17, 2021.
DOI:
File:pdf
322.
I. Lackner, T. Miclau, J. Stulz, F. Gebhard, R. Pfeifer, P. Cinelli, S. Halvachizadeh, M. Teuben, H. C. Pape, M. Lipiski, N. Cesarovic and M. Kalbitz, "Early myocardial damage (EMD) and valvular dysfunction after femur fracture in pigs", Sci Rep, vol. 11, no. 1, pp. 8503, 2021.
DOI:
File:pdf
321.
I. Lackner, M. Baur, F. Gebhard, R. Pfeifer, P. Cinelli, S. Halvachizadeh, M. Teuben, H. C. Pape, A. Imhof, M. Lipiski, N. Cesarovic and M. Kalbitz, "Early myocardial damage (EMD) and valvular insufficiency result in impaired cardiac function after multiple trauma in pigs", Sci Rep, vol. 11, no. 1, pp. 1151, 2021.
DOI:
File:pdf
320.
R. Cintean, C. Pankratz, M. Hofmann, F. Gebhard and K. Schutze, "Early Results in Non-Displaced Femoral Neck Fractures Using the Femoral Neck System", Geriatr Orthop Surg Rehabil, vol. 12, pp. 21514593211050153, 2021.
DOI:
File:
319.
F. Zink, J. Vogt, U. Wachter, J. Hartert, M. Horchler, X. Zhang, F. Hezel, T. Kapapa, T. Datzmann, A. Hoffmann, M. Wepler, E. Calzia, P. Radermacher and C. Hartmann, "Effects of Acute Subdural Hematoma-Induced Brain Injury On Energy Metabolism in Peripheral Blood Mononuclear Cells", Shock, vol. 55, no. 3, pp. 407-417, 2021.
DOI:
File: